When your nose is blocked because of sinusitis, it can feel like your whole day has been ruined. SUDAFED® Sinus Ease 0.1% Nasal Spray is here to help, targeting sinus congestion when sprayed directly into your nose, to help you breathe more easily. Works within minutes Lasts for up to 10 hours SUDAFED® Sinus Ease 0.1% Nasal Spray’s active ingredient is xylometazoline hydrochloride. This decongestant gets to work on sinus congestion quickly as it is applied directly to the nose.